Atomic imaging with liquid helium cooling

arXiv:2509.12475

Liquid Helium Cryogenic TEM below 1 Å

Demonstrates sub-angstrom atomic imaging at specimen temperatures down to about 20 K, with low stage drift and stable hold times.

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Below 1 Å information transfer at ~20 K
20 K base temperature
±2 mK thermal stability

Manuscripts

arXiv:2603.10892

Helium-Cooled Cryogenic STEM Imaging and Ptychography

Atomic-scale STEM and ptychography for low-temperature phases.

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arXiv:2509.24969

Nanoscale Polar Landscapes in Quantum Paraelectric SrTiO3

Cryogenic STEM down to 20 K reveals nanoscale polar domains in SrTiO3.

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arXiv:2509.16730

Melting point depression of charge density wave in 1T-TiSe2 due to size effects

In situ cryogenic electron microscopy down to 20 K observing size-dependent CDW nucleation and melting in nanoflake 1T-TiSe2.

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PNAS 2025

Ultracold cryogenic TEM with liquid helium and high stability

Modern TEM with liquid helium cooling and multi-day stability.

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arXiv:2509.12475

Liquid Helium Cryogenic TEM below 1 Å

Sub-angstrom atomic imaging at ultracold sample temperatures.

Read manuscript

Multi-day, Ultra-stable Cryogenic Imaging

SrTiO3 membrane image at 40 K showing 0.77 angstrom information transfer

New atomic-resolution data

SrTiO3 membrane at 40 K

The new result shows 0.77 Å information transfer with a direct-space lattice image, FFT, and magnified atomic inset.

Temperature histogram centered at 11 K showing 1.4 millikelvin sigma

Temperature stability

Precise Temperatures

Temperature feedback control maintains millikelvin-scale stability over many hours, supporting long acquisitions and low drift at ultracold specimen temperatures.

Liquid Helium Cooling Stage for Modern TEM

The h-Bar Instruments technology incorporates continuous liquid helium flow, vibration decoupling, and precise temperature feedback control to enable high-resolution imaging at ultracold sample temperatures. Lower temperatures can improve electron-beam dose resilience of sensitive specimens and provide access to emergent electronic phases in quantum materials.

Multi-day stability

Continuous liquid helium flow supports stable ultra-cold operation over extended experiments.

Low drift and vibration damping

Preserves mechanical stability needed for sub-angstrom information transfer.

Feedback temperature control

Study phase transitions from 20 K to room temperature with controlled temperature sweeps.

Available on major platforms

The flexible and modular design enables cross-platform compatibility. The h-Bar Instruments system is available on major electron microscope systems (TFS, Bruker Nion, JEOL). Turn the microscope your already have into a liquid-helium capable instrument.

Holder compatibility illustration for JEOL, Thermo Fisher Scientific, and Nion microscopes

The Team

Maya Gates, Robert Hovden, Ismail El Baggari, Emily Rennich, and Mike Blaney bring deep expertise in ultra-cold cryogenic electron microscopy for probing next-generation materials and devices at the atomic scale.

Partners

America's Seed Fund powered by NSF NSF I-Corps SPARK Oak Ridge National Laboratory Molecular Foundry Rowland Institute at Harvard Pacific Northwest National Laboratory Imperial College London University of Michigan Blueprint